TOB1 Antibody (PACO55026)
- SKU:
- PACO55026
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TOB1 Antibody (PACO55026) |
抗体コード: | PACO55026 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Protein Tob1 protein (42-175AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: NIH/3T3 whole cell lysate. All lanes: TOB1 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 39 kDa. Observed band size: 39 kDa. | |
Immunofluorescent analysis of A549 cells using PACO55026 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO55026 at dilution of 1:100. |
バックグラウンド: | Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay. |
シノニム: | Protein Tob1 (Transducer of erbB-2 1), TOB1, TOB TROB1 |
UniProt Protein Function: | TOB1: Anti-proliferative protein that interacts with the erbB- 2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors. Belongs to the BTG family. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Cell cycle regulation Chromosomal Location of Human Ortholog: 17q21 Cellular Component: CCR4-NOT complex Molecular Function:protein binding; receptor tyrosine kinase binding; SH3/SH2 adaptor activity Biological Process: negative regulation of cell proliferation; negative regulation of translation |
NCBI Summary: | This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
UniProt Code: | P50616 |
NCBI GenInfo Identifier: | 1729989 |
NCBI Gene ID: | 10140 |
NCBI Accession: | P50616.1 |
UniProt Secondary Accession: | P50616,Q4KMQ0, B2R9T0, D3DTY3, |
UniProt Related Accession: | P50616 |
Molecular Weight: | 38,155 Da |
NCBI Full Name: | Protein Tob1 |
NCBI Synonym Full Names: | transducer of ERBB2, 1 |
NCBI Official Symbol: | TOB1 |
NCBI Official Synonym Symbols: | TOB; TROB; APRO5; APRO6; PIG49; TROB1 |
NCBI Protein Information: | protein Tob1 |
UniProt Protein Name: | Protein Tob1 |
UniProt Synonym Protein Names: | Transducer of erbB-2 1 |
Protein Family: | Protein |
UniProt Gene Name: | TOB1 |
UniProt Entry Name: | TOB1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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