TNRC6A Antibody, FITC conjugated (PACO38812)
- SKU:
- PACO38812
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | TNRC6A Antibody, FITC conjugated (PACO38812) |
抗体コード: | PACO38812 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Trinucleotide repeat-containing gene 6A protein (1-161AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. |
シノニム: | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa), TNRC6A, CAGH26 KIAA1460 TNRC6 |
UniProt Protein Function: | TNRC6A: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. Belongs to the GW182 family. 6 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Translation; RNA-binding Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cytosol; Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm Molecular Function:protein binding Biological Process: miRNA-mediated gene silencing; miRNA-mediated gene silencing, negative regulation of translation; phosphoinositide-mediated signaling; RNA-mediated gene silencing; RNA-mediated posttranscriptional gene silencing; Wnt receptor signaling pathway, calcium modulating pathway |
NCBI Summary: | This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8NDV7 |
NCBI GenInfo Identifier: | 296452846 |
NCBI Gene ID: | 27327 |
NCBI Accession: | Q8NDV7.2 |
UniProt Secondary Accession: | Q8NDV7,O15408, Q658L5, Q6NVB5, Q8NEZ0, Q8TBT8, Q8TCR0 Q9NV59, Q9P268, C9JAR8, |
UniProt Related Accession: | Q8NDV7 |
Molecular Weight: | 205,151 Da |
NCBI Full Name: | Trinucleotide repeat-containing gene 6A protein |
NCBI Synonym Full Names: | trinucleotide repeat containing 6A |
NCBI Official Symbol: | TNRC6A |
NCBI Official Synonym Symbols: | GW1; GW182; TNRC6; CAGH26 |
NCBI Protein Information: | trinucleotide repeat-containing gene 6A protein |
UniProt Protein Name: | Trinucleotide repeat-containing gene 6A protein |
UniProt Synonym Protein Names: | CAG repeat protein 26; EMSY interactor protein; GW182 autoantigen; Protein GW1; Glycine-tryptophan protein of 182 kDa |
Protein Family: | Trinucleotide repeat-containing gene 6A protein |
UniProt Gene Name: | TNRC6A |
UniProt Entry Name: | TNR6A_HUMAN |