TNNT2 Antibody, HRP conjugated (PACO32809)
- SKU:
- PACO32809
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | TNNT2 Antibody, HRP conjugated (PACO32809) |
抗体コード: | PACO32809 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Troponin T, cardiac muscle protein (138-298AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
シノニム: | Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT), TNNT2 |
UniProt Protein Function: | TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1q32 Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament Molecular Function:troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; actin binding; tropomyosin binding Biological Process: atrial cardiac muscle morphogenesis; positive regulation of ATPase activity; metabolic process; regulation of muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2 |
NCBI Summary: | The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq] |
UniProt Code: | P45379 |
NCBI GenInfo Identifier: | 48255877 |
NCBI Gene ID: | 7139 |
NCBI Accession: | NP_000355.2 |
UniProt Secondary Accession: | P45379,O60214, Q99596, Q99597, Q9UM96, A2TDB9, A8K3K6 |
UniProt Related Accession: | P45379,Q15607,Q15608,Q7Z554,Q8IZA1,Q9BUF6 |
Molecular Weight: | 35,924 Da |
NCBI Full Name: | troponin T, cardiac muscle isoform 1 |
NCBI Synonym Full Names: | troponin T type 2 (cardiac) |
NCBI Official Symbol: | TNNT2 |
NCBI Official Synonym Symbols: | CMH2; RCM3; TnTC; cTnT; CMPD2; LVNC6; MGC3889 |
NCBI Protein Information: | troponin T, cardiac muscle; OTTHUMP00000033864; OTTHUMP00000033865; OTTHUMP00000033866; OTTHUMP00000033867; OTTHUMP00000033870; OTTHUMP00000218095; troponin T2, cardiac; cardiac muscle troponin T; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant) |
UniProt Protein Name: | Troponin T, cardiac muscle |
UniProt Synonym Protein Names: | Cardiac muscle troponin T |
Protein Family: | Troponin |
UniProt Gene Name: | TNNT2 |
UniProt Entry Name: | TNNT2_HUMAN |