UniProt Protein Function: | TNKS2: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP- ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. |
UniProt Protein Details: | Protein type:Nuclear envelope; EC 2.4.2.30; Transferase Chromosomal Location of Human Ortholog: 10q23.3 Cellular Component: Golgi membrane; pericentriolar material; nuclear chromosome, telomeric region; perinuclear region of cytoplasm; cytoplasm; nuclear envelope; nucleus; cytosol Molecular Function:protein binding; enzyme binding; metal ion binding; NAD+ ADP-ribosyltransferase activity Biological Process: protein amino acid ADP-ribosylation; protein polyubiquitination; Wnt receptor signaling pathway; multicellular organism growth; regulation of multicellular organism growth; positive regulation of telomere maintenance via telomerase |
UniProt Code: | Q9H2K2 |
NCBI GenInfo Identifier: | 13376842 |
NCBI Gene ID: | 80351 |
NCBI Accession: | NP_079511.1 |
UniProt Secondary Accession: | Q9H2K2,Q9H8F2, Q9HAS4, B2RBD3, |
UniProt Related Accession: | Q9H2K2 |
Molecular Weight: | 126,918 Da |
NCBI Full Name: | tankyrase-2 |
NCBI Synonym Full Names: | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 |
NCBI Official Symbol: | TNKS2 |
NCBI Official Synonym Symbols: | TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c |
NCBI Protein Information: | tankyrase-2; ADP-ribosyltransferase diphtheria toxin-like 6; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; poly [ADP-ribose] polymerase 5B; tankyrase 2; tankyrase II; tankyrase-like protein; tankyrase-related protein |
UniProt Protein Name: | Tankyrase-2 |
UniProt Synonym Protein Names: | ADP-ribosyltransferase diphtheria toxin-like 6; ARTD6; Poly [ADP-ribose] polymerase 5B; TNKS-2; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; Tankyrase II; Tankyrase-like protein; Tankyrase-related protein |
Protein Family: | Tankyrase |
UniProt Gene Name: | TNKS2 |
UniProt Entry Name: | TNKS2_HUMAN |