TNFSF9 Antibody (PACO06328)
- SKU:
- PACO06328
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TNFSF9 Antibody (PACO06328) |
抗体コード: | PACO06328 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | ELISA:1:20000, IF:1:200-1:1000 |
反応性: | Human |
免疫原: | Synthesized peptide derived from the Internal region of human CD137L. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | TNFSF9; Tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL |
UniProt Protein Function: | TNFL9: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family. |
UniProt Protein Details: | Protein type:Apoptosis; Cell cycle regulation; Cytokine; Membrane protein, integral Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: plasma membrane Molecular Function:receptor binding; tumor necrosis factor receptor superfamily binding Biological Process: apoptosis; cell proliferation; cell-cell signaling; positive regulation of activated T cell proliferation; positive regulation of cytotoxic T cell differentiation; signal transduction; tumor necrosis factor-mediated signaling pathway |
NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008] |
UniProt Code: | P41273 |
NCBI GenInfo Identifier: | 728739 |
NCBI Gene ID: | 8744 |
NCBI Accession: | P41273.1 |
UniProt Secondary Accession: | P41273,Q2M3S2, |
UniProt Related Accession: | P41273 |
Molecular Weight: | 27kDa |
NCBI Full Name: | Tumor necrosis factor ligand superfamily member 9 |
NCBI Synonym Full Names: | TNF superfamily member 9 |
NCBI Official Symbol: | TNFSF9 |
NCBI Official Synonym Symbols: | CD137L; TNLG5A; 4-1BB-L |
NCBI Protein Information: | tumor necrosis factor ligand superfamily member 9 |
UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 9 |
UniProt Synonym Protein Names: | 4-1BB ligand; 4-1BBL |
Protein Family: | Tumor necrosis factor ligand superfamily |
UniProt Gene Name: | TNFSF9 |