UniProt Protein Function: | TNFRSF8: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1p36 Cellular Component: cytoplasm; integral to membrane; plasma membrane Molecular Function:transmembrane receptor activity Biological Process: positive regulation of tumor necrosis factor biosynthetic process; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; signal transduction |
NCBI Summary: | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
UniProt Code: | P28908 |
NCBI GenInfo Identifier: | 115978 |
NCBI Gene ID: | 943 |
NCBI Accession: | P28908.1 |
UniProt Secondary Accession: | P28908,Q6P4D9, B1AN79, B9EGD9, D3YTD8, |
UniProt Related Accession: | P28908 |
Molecular Weight: | 50,935 Da |
NCBI Full Name: | Tumor necrosis factor receptor superfamily member 8 |
NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily, member 8 |
NCBI Official Symbol: | TNFRSF8 |
NCBI Official Synonym Symbols: | CD30; Ki-1; D1S166E |
NCBI Protein Information: | tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30 |
UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 8 |
UniProt Synonym Protein Names: | CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD_antigen: CD30 |
UniProt Gene Name: | TNFRSF8 |
UniProt Entry Name: | TNR8_HUMAN |