UniProt Protein Function: | TNC: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Belongs to the tenascin family. 6 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 9q33 Cellular Component: basement membrane; extracellular matrix; extracellular region; extracellular space; focal adhesion; membrane Molecular Function:syndecan binding Biological Process: axon regeneration in the peripheral nervous system; cell adhesion; extracellular matrix organization and biogenesis; negative regulation of cell adhesion; neuromuscular junction development; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of cell proliferation; response to ethanol; response to mechanical stimulus; response to wounding; wound healing Disease: Deafness, Autosomal Dominant 56 |
NCBI Summary: | This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011] |
UniProt Code: | P24821 |
NCBI GenInfo Identifier: | 281185495 |
NCBI Gene ID: | 3371 |
NCBI Accession: | P24821.3 |
UniProt Secondary Accession: | P24821,Q14583, Q15567, Q5T7S3, C9IYT7, C9J575, C9J6D9 C9J848, |
UniProt Related Accession: | P24821 |
Molecular Weight: | 171,360 Da |
NCBI Full Name: | Tenascin |
NCBI Synonym Full Names: | tenascin C |
NCBI Official Symbol: | TNC |
NCBI Official Synonym Symbols: | GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225 |
NCBI Protein Information: | tenascin |
UniProt Protein Name: | Tenascin |
UniProt Synonym Protein Names: | Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin-C; TN-C |
Protein Family: | Tenascin |
UniProt Gene Name: | TNC |
UniProt Entry Name: | TENA_HUMAN |