TMEM106B Antibody (PACO12792)
- SKU:
- PACO12792
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TMEM106B Antibody (PACO12792) |
抗体コード: | PACO12792 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human |
免疫原: | Human TMEM106B |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | transmembrane protein 106B;TMEM106B;FLJ11273;MGC33727 ; |
UniProt Protein Function: | TMEM106B: TMEM106B genotype, when containing 3 particular single-nucleotide polymorphisms, is strongly correlated with frontotemporal lobar degeneration with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP). Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia and 20% of patients with this neurodegenerative disease have autosomal dominant GRN mutations. Expression of TMEM106B associated with these polymorphisms is increased in frontal cortex of patients with FTLD-TDP compared to unaffected controls. Thus, increased TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression. Belongs to the TMEM106 family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 7p21.3Cellular Component: intracellular membrane-bound organelle; lysosomal membrane; late endosome membrane; integral to membraneMolecular Function: protein bindingBiological Process: lysosome localization; transport; dendrite morphogenesis |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q9NUM4 |
NCBI GenInfo Identifier: | 109895058 |
NCBI Gene ID: | |
NCBI Accession: | Q9NUM4.2 |
UniProt Secondary Accession: | Q9NUM4 |
UniProt Related Accession: | Q9NUM4 |
Molecular Weight: | |
NCBI Full Name: | Transmembrane protein 106B |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | |
UniProt Protein Name: | Transmembrane protein 106B |
UniProt Synonym Protein Names: | |
Protein Family: | Transmembrane protein |
UniProt Gene Name: | TMEM106B |
UniProt Entry Name: | T106B_HUMAN |