TIMP4 Antibody (PACO01630)
- SKU:
- PACO01630
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TIMP4 Antibody |
抗体コード: | PACO01630 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from the C-terminal region of human TIMP-4. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | TIMP4; Metalloproteinase inhibitor 4; Tissue inhibitor of metalloproteinases 4; TIMP-4 |
UniProt Protein Function: | TIMP4: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9. Belongs to the protease inhibitor I35 (TIMP) family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3p25 Cellular Component: extracellular space; proteinaceous extracellular matrix; sarcomere Molecular Function:metal ion binding; metalloendopeptidase inhibitor activity; protease binding Biological Process: central nervous system development; negative regulation of membrane protein ectodomain proteolysis; negative regulation of metalloenzyme activity; Notch signaling pathway; ovulation cycle; response to cytokine stimulus; response to drug; response to lipopolysaccharide; response to organic substance; response to peptide hormone stimulus |
NCBI Summary: | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99727 |
NCBI GenInfo Identifier: | 3915135 |
NCBI Gene ID: | 7079 |
NCBI Accession: | Q99727.1 |
UniProt Secondary Accession: | Q99727,B2R7K6, |
UniProt Related Accession: | Q99727 |
Molecular Weight: | 25,503 Da |
NCBI Full Name: | Metalloproteinase inhibitor 4 |
NCBI Synonym Full Names: | TIMP metallopeptidase inhibitor 4 |
NCBI Official Symbol: | TIMP4 |
NCBI Protein Information: | metalloproteinase inhibitor 4 |
UniProt Protein Name: | Metalloproteinase inhibitor 4 |
UniProt Synonym Protein Names: | Tissue inhibitor of metalloproteinases 4; TIMP-4 |
Protein Family: | Metalloproteinase inhibitor |
UniProt Gene Name: | TIMP4 |
UniProt Entry Name: | TIMP4_HUMAN |