TIMP3 Antibody (PACO15115)
- SKU:
- PACO15115
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TIMP3 Antibody (PACO15115) |
抗体コード: | PACO15115 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:15-1:50 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human TIMP3 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15115(TIMP3 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Huvec cells, Primary antibody: PACO15115(TIMP3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15115(TIMP3 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. |
シノニム: | TIMP metallopeptidase inhibitor 3 |
UniProt Protein Function: | TIMP3: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Interacts with EFEMP1. Belongs to the protease inhibitor I35 (TIMP) family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 22q12.3 Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; basement membrane; nucleus Molecular Function:metalloendopeptidase inhibitor activity; protein binding; protease binding; metal ion binding Biological Process: negative regulation of metalloenzyme activity; visual perception; response to cytokine stimulus; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis Disease: Fundus Dystrophy, Pseudoinflammatory, Of Sorsby |
NCBI Summary: | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008] |
UniProt Code: | P35625 |
NCBI GenInfo Identifier: | 730948 |
NCBI Gene ID: | 7078 |
NCBI Accession: | P35625.2 |
UniProt Secondary Accession: | P35625,Q5THV4, Q9UC74, Q9UGS2, B2RBY9, |
UniProt Related Accession: | P35625 |
Molecular Weight: | 24,145 Da |
NCBI Full Name: | Metalloproteinase inhibitor 3 |
NCBI Synonym Full Names: | TIMP metallopeptidase inhibitor 3 |
NCBI Official Symbol: | TIMP3 |
NCBI Official Synonym Symbols: | SFD; K222; K222TA2; HSMRK222 |
NCBI Protein Information: | metalloproteinase inhibitor 3; TIMP-3; MIG-5 protein; protein MIG-5; tissue inhibitor of metalloproteinases 3 |
UniProt Protein Name: | Metalloproteinase inhibitor 3 |
UniProt Synonym Protein Names: | Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3 |
Protein Family: | Metalloproteinase inhibitor |
UniProt Gene Name: | TIMP3 |
UniProt Entry Name: | TIMP3_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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