TIMM8B Antibody (PACO42874)
- SKU:
- PACO42874
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | TIMM8B Antibody (PACO42874) |
抗体コード: | PACO42874 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Mitochondrial import inner membrane translocase subunit Tim8 B protein (33-83AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO42874 at dilution of 1:100. |
バックグラウンド: | Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). |
シノニム: | Mitochondrial import inner membrane translocase subunit Tim8 B (DDP-like protein) (Deafness dystonia protein 2), TIMM8B, DDP2 DDPL TIM8B |
UniProt Protein Function: | Function: Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space |
UniProt Protein Details: | By similarity. Subunit structure: Heterohexamer; possibly composed of 3 copies of TIMM8B and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 By similarity. Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side By similarity. Tissue specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. Ref.2 Domain: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM8B from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane By similarity. Sequence similarities: Belongs to the small Tim family. |
NCBI Summary: | This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009] |
UniProt Code: | Q9Y5J9 |
NCBI GenInfo Identifier: | 6524627 |
NCBI Gene ID: | 26521 |
NCBI Accession: | AAF15100.1 |
UniProt Secondary Accession: | Q9Y5J9,P62077, P62078, |
UniProt Related Accession: | Q9Y5J9 |
Molecular Weight: | 9,344 Da |
NCBI Full Name: | TIMM8b |
NCBI Synonym Full Names: | translocase of inner mitochondrial membrane 8 homolog B (yeast) |
NCBI Official Symbol: | TIMM8B |
NCBI Official Synonym Symbols: | DDP2; TIM8B |
NCBI Protein Information: | mitochondrial import inner membrane translocase subunit Tim8 B; DDP-like protein; deafness dystonia protein 2 |
UniProt Protein Name: | Mitochondrial import inner membrane translocase subunit Tim8 B |
UniProt Synonym Protein Names: | DDP-like protein; Deafness dystonia protein 2 |
UniProt Gene Name: | TIMM8B |
UniProt Entry Name: | TIM8B_HUMAN |
Antibodies |
Anti-TIMM8B Antibody (CAB15814) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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