TIMM50 Antibody (PACO45554)
- SKU:
- PACO45554
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TIMM50 Antibody (PACO45554) |
抗体コード: | PACO45554 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
反応性: | Human, Rat |
免疫原: | Recombinant Human Mitochondrial import inner membrane translocase subunit TIM50 protein (87-353AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: TIMM50 antibody at 4.05µg/ml. Lane 1: Rat heart tissue. Lane 2: MM231 whole cell lysate. Lane 3: MCF-7 whole cell lysate. Lane 4: Hela whole cell lysate. Lane 5: 293T whole cell lysate. Lane 6: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 40, 51, 28 kDa. Observed band size: 40 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO45554 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human liver tissue using PACO45554 at dilution of 1:100. |
バックグラウンド: | Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body. |
シノニム: | Mitochondrial import inner membrane translocase subunit TIM50, TIMM50, TIM50 |
UniProt Protein Function: | TIMM50: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body. Belongs to the TIM50 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Mitochondrial; Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: mitochondrial inner membrane; mitochondrial inner membrane presequence translocase complex; mitochondrion; nuclear speck; nucleoplasm Molecular Function:interleukin-2 receptor binding; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; ribonucleoprotein binding Biological Process: mitochondrial membrane organization and biogenesis; protein amino acid dephosphorylation; protein import into mitochondrial matrix; release of cytochrome c from mitochondria |
NCBI Summary: | This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis. [provided by RefSeq, Jul 2016] |
UniProt Code: | Q3ZCQ8 |
NCBI GenInfo Identifier: | 83305924 |
NCBI Gene ID: | 92609 |
NCBI Accession: | Q3ZCQ8.2 |
UniProt Secondary Accession: | Q3ZCQ8,Q330K1, Q6QA00, Q96FJ5, Q96GY2, Q9H370, |
UniProt Related Accession: | Q3ZCQ8 |
Molecular Weight: | 27,579 Da |
NCBI Full Name: | Mitochondrial import inner membrane translocase subunit TIM50 |
NCBI Synonym Full Names: | translocase of inner mitochondrial membrane 50 |
NCBI Official Symbol: | TIMM50 |
NCBI Official Synonym Symbols: | TIM50; TIM50L |
NCBI Protein Information: | mitochondrial import inner membrane translocase subunit TIM50 |
UniProt Protein Name: | Mitochondrial import inner membrane translocase subunit TIM50 |
Protein Family: | Mitochondrial import inner membrane translocase |
UniProt Gene Name: | TIMM50 |
UniProt Entry Name: | TIM50_HUMAN |
Antibodies |
Anti-TIMM50 Antibody (CAB9991) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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