THOC7 Antibody, FITC conjugated (PACO36816)
- SKU:
- PACO36816
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | THOC7 Antibody, FITC conjugated (PACO36816) |
抗体コード: | PACO36816 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human THO complex subunit 7 homolog protein (4-204AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. |
シノニム: | THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30), THOC7, NIF3L1BP1 |
UniProt Protein Function: | THOC7: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. Belongs to the THOC7 family. |
UniProt Protein Details: | Protein type:RNA splicing; Spliceosome Chromosomal Location of Human Ortholog: 3p14.1 Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleus Molecular Function:nucleic acid binding; protein binding Biological Process: intronless viral mRNA export from host nucleus; mRNA 3'-end processing; mRNA export from nucleus; RNA elongation from RNA polymerase II promoter; RNA export from nucleus; termination of RNA polymerase II transcription |
UniProt Code: | Q6I9Y2 |
NCBI GenInfo Identifier: | 229462996 |
NCBI Gene ID: | 80145 |
NCBI Accession: | Q6I9Y2.3 |
UniProt Secondary Accession: | Q6I9Y2,Q6P1L3, Q8WUF2, Q9H5H0, |
UniProt Related Accession: | Q6I9Y2 |
Molecular Weight: | 23,743 Da |
NCBI Full Name: | THO complex subunit 7 homolog |
NCBI Synonym Full Names: | THO complex 7 |
NCBI Official Symbol: | THOC7 |
NCBI Official Synonym Symbols: | fSAP24; hTREX30; NIF3L1BP1 |
NCBI Protein Information: | THO complex subunit 7 homolog |
UniProt Protein Name: | THO complex subunit 7 homolog |
UniProt Synonym Protein Names: | Functional spliceosome-associated protein 24; fSAP24; Ngg1-interacting factor 3-like protein 1-binding protein 1; NIF3L1-binding protein 1; hTREX30 |
Protein Family: | THO complex |
UniProt Gene Name: | THOC7 |
UniProt Entry Name: | THOC7_HUMAN |