THOC5 Antibody, FITC conjugated (PACO57090)
- SKU:
- PACO57090
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | THOC5 Antibody, FITC conjugated (PACO57090) |
抗体コード: | PACO57090 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human THO complex subunit 5 homolog protein (2-53AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes. |
シノニム: | THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90), THOC5, C22orf19 KIAA0983 |
UniProt Protein Function: | FMIP: a Fms-interacting protein. Binds transiently to activated Fms. Phosphorylation by protein kinase C has been reported to potentiates M-CSF-mediated differentiation. Overexpression inhibited M-CSF induced macrophage differentiation and enhanced granulocytic differentiation. |
UniProt Protein Details: | Protein type:Cell development/differentiation; RNA splicing; Spliceosome Chromosomal Location of Human Ortholog: 22q12.2 Cellular Component: nuclear chromosome, telomeric region; nucleoplasm; nucleus Molecular Function:mRNA binding; protein binding Biological Process: intronless viral mRNA export from host nucleus; monocyte differentiation; mRNA 3'-end processing; mRNA export from nucleus; positive regulation of RNA elongation; RNA export from nucleus; termination of RNA polymerase II transcription |
UniProt Code: | Q13769 |
NCBI GenInfo Identifier: | 259016156 |
NCBI Gene ID: | 8563 |
NCBI Accession: | Q13769.2 |
UniProt Secondary Accession: | Q13769,O60839, Q9UPZ5, |
UniProt Related Accession: | Q13769 |
Molecular Weight: | 79kDa |
NCBI Full Name: | THO complex subunit 5 homolog |
NCBI Synonym Full Names: | THO complex 5 |
NCBI Official Symbol: | THOC5 |
NCBI Official Synonym Symbols: | Fmip; PK1.3; fSAP79; C22orf19 |
NCBI Protein Information: | THO complex subunit 5 homolog |
UniProt Protein Name: | THO complex subunit 5 homolog |
UniProt Synonym Protein Names: | Functional spliceosome-associated protein 79; fSAP79; NF2/meningioma region protein pK1.3; Placental protein 39.2; PP39.2; hTREX90 |
Protein Family: | THO complex |
UniProt Gene Name: | THOC5 |