UniProt Protein Function: | THEMIS: Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. Interacts with PLCG1, ITK and GRB2. Belongs to the themis family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Cell development/differentiationChromosomal Location of Human Ortholog: 6q22.33Cellular Component: cytoplasm; intercellular junction; nucleus; signalosomeMolecular Function: protein bindingBiological Process: adaptive immune response; negative T cell selection; positive T cell selection; T cell receptor signaling pathway |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] |
UniProt Code: | Q8N1K5 |
NCBI GenInfo Identifier: | 150421530 |
NCBI Gene ID: | 387357 |
NCBI Accession: | Q8N1K5.3 |
UniProt Secondary Accession: | Q8N1K5,Q5T3C4, Q5T3C5, Q6MZT7, A1L4F0, A8K7N1, B3KT31 B3KW32, B3KY07, F5H1J9 |
UniProt Related Accession: | Q8N1K5 |
Molecular Weight: | 77,515 Da |
NCBI Full Name: | Protein THEMIS |
NCBI Synonym Full Names: | thymocyte selection associated |
NCBI Official Symbol: | THEMIS |
NCBI Official Synonym Symbols: | GASP; SPOT; TSEPA; C6orf190; C6orf207 |
NCBI Protein Information: | protein THEMIS |
UniProt Protein Name: | Protein THEMIS |
UniProt Synonym Protein Names: | Thymocyte-expressed molecule involved in selection |
Protein Family: | Protein |
UniProt Gene Name: | THEMIS |
UniProt Entry Name: | THMS1_HUMAN |