TGM1 Antibody (PACO20748)
- SKU:
- PACO20748
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TGM1 Antibody (PACO20748) |
抗体コード: | PACO20748 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Synthetic peptide of human TGM1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20748(TGM1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). |
シノニム: | transglutaminase 1 |
UniProt Protein Function: | TGM1: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. |
UniProt Protein Details: | Protein type:Transferase; EC 2.3.2.13 Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: cell-cell adherens junction; cornified envelope; intrinsic to membrane Molecular Function:protein binding; protein-glutamine gamma-glutamyltransferase activity; metal ion binding Biological Process: cell envelope organization and biogenesis; keratinocyte differentiation; organ morphogenesis; keratinization; protein modification process; peptide cross-linking Disease: Ichthyosis, Congenital, Autosomal Recessive 1 |
NCBI Summary: | The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008] |
UniProt Code: | P22735 |
NCBI GenInfo Identifier: | 57015359 |
NCBI Gene ID: | 7051 |
NCBI Accession: | P22735.4 |
UniProt Related Accession: | P22735 |
Molecular Weight: | Observed: 90 kDaPredicted: 90 kDa |
NCBI Full Name: | Protein-glutamine gamma-glutamyltransferase K |
NCBI Synonym Full Names: | transglutaminase 1 |
NCBI Official Symbol: | TGM1 |
NCBI Official Synonym Symbols: | LI; KTG; LI1; TGK; ICR2; ARCI1; TGASE |
NCBI Protein Information: | protein-glutamine gamma-glutamyltransferase K |
UniProt Protein Name: | Protein-glutamine gamma-glutamyltransferase K |
UniProt Synonym Protein Names: | Epidermal TGase; Transglutaminase K; TG(K); TGK; TGase K; Transglutaminase-1; TGase-1 |
Protein Family: | Protein-glutamine gamma-glutamyltransferase |
UniProt Gene Name: | TGM1 |
UniProt Entry Name: | TGM1_HUMAN |
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