TGFB1 Antibody (PACO30346)
- SKU:
- PACO30346
- Product type:
- Antibody
- Reactivity:
- Bovine
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TGFB1 Antibody (PACO30346) |
抗体コード: | PACO30346 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Bovine |
免疫原: | Recombinant Bovine Transforming growth factor beta-1 proprotein protein (279-390AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
バックグラウンド: | Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). |
シノニム: | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP)], (Transforming growth factor beta-1) (TGF-beta-1) TGFB1 |
UniProt Protein Function: | Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (). |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | P18341 |
NCBI GenInfo Identifier: | 260655603 |
NCBI Gene ID: | 282089 |
NCBI Accession: | NP_001159540.1 |
UniProt Secondary Accession: | P18341,A5A3B8 |
UniProt Related Accession: | P18341 |
Molecular Weight: | 44,409 Da |
NCBI Full Name: | transforming growth factor beta-1 |
NCBI Synonym Full Names: | transforming growth factor beta 1 |
NCBI Official Symbol: | TGFB1 |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | transforming growth factor beta-1 |
UniProt Protein Name: | Transforming growth factor beta-1 |
UniProt Synonym Protein Names: | |
Protein Family: | Transforming growth factor |
UniProt Gene Name: | TGFB1 |
UniProt Entry Name: |