TFB2M Antibody, HRP conjugated (PACO51039)
- SKU:
- PACO51039
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | TFB2M Antibody, HRP conjugated (PACO51039) |
抗体コード: | PACO51039 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Dimethyladenosine transferase 2, mitochondrial protein (30-108AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. |
シノニム: | Dimethyladenosine transferase 2, mitochondrial (EC 2.1.1) (Hepatitis C virus NS5A-transactivated protein 5) (HCV NS5A-transactivated protein 5) (Mitochondrial 12S rRNA dimethylase 2) (Mitochondrial transcription factor B2) (h-mtTFB) (h-mtTFB2) (hTFB2M) (mtTFB2) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2), TFB2M, NS5ATP5 |
UniProt Protein Function: | TFB2M: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily. |
UniProt Protein Details: | Protein type:EC 2.1.1.-; Methyltransferase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1q44 Cellular Component: mitochondrial matrix Molecular Function:rRNA (adenine-N6,N6-)-dimethyltransferase activity; transcription cofactor activity Biological Process: mitochondrion organization and biogenesis; positive regulation of transcription, DNA-dependent; organelle organization and biogenesis; rRNA methylation; gene expression; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter |
UniProt Code: | Q9H5Q4 |
NCBI GenInfo Identifier: | 11641289 |
NCBI Gene ID: | 64216 |
NCBI Accession: | NP_071761.1 |
UniProt Related Accession: | Q9H5Q4 |
Molecular Weight: | 45kDa |
NCBI Full Name: | dimethyladenosine transferase 2, mitochondrial |
NCBI Synonym Full Names: | transcription factor B2, mitochondrial |
NCBI Official Symbol: | TFB2M |
NCBI Official Synonym Symbols: | Hkp1; mtTFB2 |
NCBI Protein Information: | dimethyladenosine transferase 2, mitochondrial |
UniProt Protein Name: | Dimethyladenosine transferase 2, mitochondrial |
UniProt Synonym Protein Names: | Hepatitis C virus NS5A-transactivated protein 5; HCV NS5A-transactivated protein 5; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; h-mtTFB; h-mtTFB2; hTFB2M; mtTFB2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2 |
Protein Family: | Dimethyladenosine transferase |
UniProt Gene Name: | TFB2M |
UniProt Entry Name: | TFB2M_HUMAN |