TFAP2C Antibody, FITC conjugated (PACO54160)
- SKU:
- PACO54160
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | TFAP2C Antibody, FITC conjugated (PACO54160) |
抗体コード: | PACO54160 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Transcription factor AP-2 γ protein (8-180AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP α and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. |
シノニム: | Transcription factor AP-2 γ (AP2-gamma) (Activating enhancer-binding protein 2 gamma) (Transcription factor ERF-1), TFAP2C |
UniProt Protein Function: | AP-2 gamma: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. During retinoic acid-mediated differentiation. Belongs to the AP-2 family. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 20q13.2 Cellular Component: mitochondrion; nucleoplasm; nucleus Molecular Function:DNA binding; protein binding; protein dimerization activity; transcription factor activity Biological Process: cell-cell signaling; male gonad development; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of gene expression, epigenetic; regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q92754 |
NCBI GenInfo Identifier: | 12643310 |
NCBI Gene ID: | 7022 |
NCBI Accession: | Q92754.1 |
UniProt Secondary Accession: | Q92754,O00685, O00730, Q86V30, Q8IVB6, Q9P1X2, B4DWK3 |
UniProt Related Accession: | Q92754 |
Molecular Weight: | 31,010 Da |
NCBI Full Name: | Transcription factor AP-2 gamma |
NCBI Synonym Full Names: | transcription factor AP-2 gamma |
NCBI Official Symbol: | TFAP2C |
NCBI Official Synonym Symbols: | ERF1; TFAP2G; hAP-2g; AP2-GAMMA |
NCBI Protein Information: | transcription factor AP-2 gamma |
UniProt Protein Name: | Transcription factor AP-2 gamma |
UniProt Synonym Protein Names: | Activating enhancer-binding protein 2 gamma; Transcription factor ERF-1 |
Protein Family: | Transcription factor |
UniProt Gene Name: | TFAP2C |
UniProt Entry Name: | AP2C_HUMAN |