TFAP2B Antibody, Biotin conjugated (PACO55197)
- SKU:
- PACO55197
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | TFAP2B Antibody, Biotin conjugated (PACO55197) |
抗体コード: | PACO55197 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Transcription factor AP-2-β protein (111-208AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP α and MYC. AP-2-β appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. |
シノニム: | Transcription factor AP-2-β (AP2-beta) (Activating enhancer-binding protein 2-beta), TFAP2B |
UniProt Protein Function: | AP-2 beta: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Belongs to the AP-2 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 6p12 Cellular Component: nucleus Molecular Function:caspase inhibitor activity; DNA binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity Biological Process: calcium ion homeostasis; fat cell differentiation; forelimb morphogenesis; glucose homeostasis; glucose metabolic process; hindlimb morphogenesis; kidney development; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphate ion homeostasis; positive regulation of cell proliferation; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; potassium ion homeostasis; regulation of BMP signaling pathway; regulation of cell differentiation; regulation of insulin secretion; regulation of transcription, DNA-dependent; renal water homeostasis; sodium ion homeostasis; sympathetic nervous system development Disease: Char Syndrome |
NCBI Summary: | This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q92481 |
NCBI GenInfo Identifier: | 152031557 |
NCBI Gene ID: | 7021 |
NCBI Accession: | Q92481.2 |
UniProt Secondary Accession: | Q92481,Q5JYX6, Q9NQ63, Q9NU99, Q9UJI7, Q9Y214, Q9Y3K3 |
UniProt Related Accession: | Q92481 |
Molecular Weight: | 51,524 Da |
NCBI Full Name: | Transcription factor AP-2-beta |
NCBI Synonym Full Names: | transcription factor AP-2 beta |
NCBI Official Symbol: | TFAP2B |
NCBI Official Synonym Symbols: | PDA2; AP-2B; AP2-B |
NCBI Protein Information: | transcription factor AP-2-beta |
UniProt Protein Name: | Transcription factor AP-2-beta |
UniProt Synonym Protein Names: | Activating enhancer-binding protein 2-beta |
Protein Family: | Transcription factor |
UniProt Gene Name: | TFAP2B |
UniProt Entry Name: | AP2B_HUMAN |