TET3 Antibody (PACO30326)
- SKU:
- PACO30326
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TET3 Antibody (PACO30326) |
抗体コード: | PACO30326 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Methylcytosine dioxygenase TET3 protein (72-335AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human liver tissue using PACO30326 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO30326 at dilution of 1:100. |
バックグラウンド: | Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. |
シノニム: | Methylcytosine dioxygenase TET3 (EC 1.14.11.n2), TET3, KIAA0401 |
UniProt Protein Function: | TET3: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Conversion into 5hmC initiates a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. Belongs to the TET family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 1.14.11.n2; Oxidoreductase Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: male pronucleus; cytoplasm; female pronucleus Molecular Function:protein binding; DNA binding; metal ion binding Biological Process: protein amino acid O-linked glycosylation; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic |
NCBI Summary: | Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010] |
UniProt Code: | O43151 |
NCBI GenInfo Identifier: | 190358928 |
NCBI Gene ID: | 200424 |
NCBI Accession: | O43151.3 |
UniProt Secondary Accession: | O43151,Q86Z24, Q8TBM9, A6NEI3, |
UniProt Related Accession: | O43151 |
Molecular Weight: | Calculated MW: 77kDa/166kDa/179kDaObserved MW: 200kDa |
NCBI Full Name: | Methylcytosine dioxygenase TET3 |
NCBI Synonym Full Names: | tet methylcytosine dioxygenase 3 |
NCBI Official Symbol: | TET3 |
NCBI Official Synonym Symbols: | hCG_40738 |
NCBI Protein Information: | methylcytosine dioxygenase TET3 |
UniProt Protein Name: | Methylcytosine dioxygenase TET3 |
Protein Family: | Tetraspanin |
UniProt Gene Name: | TET3 |
UniProt Entry Name: | TET3_HUMAN |
Antibodies |
Anti-TET3 Antibody (CAB13453) |
Anti-TET3 Antibody (CAB17310) |
Anti-TET3 Antibody (CAB3141) |
Anti-TET3 Antibody (CAB7612) |
Anti-TET3 Antibody (CAB18319) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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