TEAD3 Antibody (PACO40298)
- SKU:
- PACO40298
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TEAD3 Antibody (PACO40298) |
抗体コード: | PACO40298 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
反応性: | Human |
免疫原: | Recombinant Human Transcriptional enhancer factor TEF-5 protein (112-435AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO40298 diluted at 1:1000 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | IHC image of PACO40298 diluted at 1:1000 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. |
シノニム: | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3), TEAD3, TEAD5 TEF5 |
UniProt Protein Function: | TEAD3: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. |
UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 6p21.2 Cellular Component: nucleoplasm Molecular Function:protein binding; transcription factor activity Biological Process: asymmetric neuroblast division; female pregnancy; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter |
NCBI Summary: | This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99594 |
NCBI GenInfo Identifier: | 2501157 |
NCBI Gene ID: | 7005 |
NCBI Accession: | Q99594.2 |
UniProt Secondary Accession: | Q99594,O95910, Q5BJG7, Q8N6Y4, |
UniProt Related Accession: | Q99594 |
Molecular Weight: | 48,676 Da |
NCBI Full Name: | Transcriptional enhancer factor TEF-5 |
NCBI Synonym Full Names: | TEA domain transcription factor 3 |
NCBI Official Symbol: | TEAD3 |
NCBI Official Synonym Symbols: | TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3 |
NCBI Protein Information: | transcriptional enhancer factor TEF-5 |
UniProt Protein Name: | Transcriptional enhancer factor TEF-5 |
UniProt Synonym Protein Names: | DTEF-1; TEA domain family member 3; TEAD-3 |
Protein Family: | Transcriptional enhancer factor |
UniProt Gene Name: | TEAD3 |
UniProt Entry Name: | TEAD3_HUMAN |
Antibodies | ELISA Kits |
Anti-TEAD3 Antibody (CAB7454) | TEAD3 Transcription Factor Activity Assay |
TEAD3 Antibody (PACO05190) | |
TEAD3 Antibody (PACO12691) |
Secondary Antibody |
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