UniProt Protein Function: | TTRAP: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'- phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Has also 3'- tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'- tyrosyl-DNA phosphodiesterase in cells. Also acts as a 5'-tyrosyl- RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA. Also acts as an adapter by participating to the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF- beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non- canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stress. Belongs to the CCR4/nocturin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Nucleolus; Inhibitor; EC 3.1.4.- Chromosomal Location of Human Ortholog: 6p22.3-p22.1 Cellular Component: nucleoplasm; PML body; intercellular bridge; cytoplasm; nucleolus; nucleus Molecular Function:protein binding; nuclease activity; manganese ion binding; magnesium ion binding; transcription corepressor activity; single-stranded DNA binding Biological Process: cell surface receptor linked signal transduction; double-strand break repair |
NCBI Summary: | This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95551 |
NCBI GenInfo Identifier: | 67462008 |
NCBI Gene ID: | 51567 |
NCBI Accession: | O95551.1 |
UniProt Secondary Accession: | O95551,Q2TBE2, Q5JYM0, Q7Z6U5, Q9NUK5, Q9NYY9, B4DKL8 B4DQ95, |
UniProt Related Accession: | O95551 |
Molecular Weight: | 362 |
NCBI Full Name: | Tyrosyl-DNA phosphodiesterase 2 |
NCBI Synonym Full Names: | tyrosyl-DNA phosphodiesterase 2 |
NCBI Official Symbol: | TDP2 |
NCBI Official Synonym Symbols: | EAP2; AD022; EAPII; TTRAP; hTDP2; dJ30M3.3 |
NCBI Protein Information: | tyrosyl-DNA phosphodiesterase 2; VPg unlinkase; ETS1-associated protein 2; ETS1-associated protein II; tyr-DNA phosphodiesterase 2; 5'-Tyr-DNA phosphodiesterase; tyrosyl-RNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; TRAF and TNF receptor associ |
UniProt Protein Name: | Tyrosyl-DNA phosphodiesterase 2 |
UniProt Synonym Protein Names: | 5'-tyrosyl-DNA phosphodiesterase; 5'-Tyr-DNA phosphodiesterase; ETS1-associated protein 2; ETS1-associated protein II; EAPII; TRAF and TNF receptor-associated protein; Tyrosyl-RNA phosphodiesterase; VPg unlinkase |
Protein Family: | Tyrosyl-DNA phosphodiesterase |
UniProt Gene Name: | TDP2 |
UniProt Entry Name: | TYDP2_HUMAN |