TCF3 Antibody, Biotin conjugated (PACO47709)
- SKU:
- PACO47709
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | TCF3 Antibody, Biotin conjugated (PACO47709) |
抗体コード: | PACO47709 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Transcription factor E2-α protein (415-658AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the κ immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. |
シノニム: | Transcription factor E2-α (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1), TCF3, BHLHB21 E2A ITF1 |
UniProt Protein Function: | E2A: a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding; Oncoprotein Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex Molecular Function:bHLH transcription factor binding; DNA binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription coactivator activity; transcription factor activity; transcription factor binding Biological Process: immunoglobulin V(D)J recombination; negative regulation of transcription from RNA polymerase II promoter; positive regulation of muscle cell differentiation; positive regulation of neuron differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent |
NCBI Summary: | This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011] |
UniProt Code: | P15923 |
NCBI GenInfo Identifier: | 135655 |
NCBI Gene ID: | 6929 |
NCBI Accession: | P15923.1 |
UniProt Secondary Accession: | P15923,P15883, Q14208, Q14635, Q14636, Q2TB39, Q2TB40 Q9UPI9, |
UniProt Related Accession: | P15923 |
Molecular Weight: | 68,510 Da |
NCBI Full Name: | Transcription factor E2-alpha |
NCBI Synonym Full Names: | transcription factor 3 |
NCBI Official Symbol: | TCF3 |
NCBI Official Synonym Symbols: | E2A; E47; AGM8; ITF1; VDIR; TCF-3; bHLHb21 |
NCBI Protein Information: | transcription factor E2-alpha |
UniProt Protein Name: | Transcription factor E2-alpha |
UniProt Synonym Protein Names: | Class B basic helix-loop-helix protein 21; bHLHb21; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription factor 3; TCF-3; Transcription factor ITF-1 |
Protein Family: | TCF3 fusion partner |
UniProt Gene Name: | TCF3 |
UniProt Entry Name: | TFE2_HUMAN |