TBX21 Antibody, Biotin conjugated (PACO49357)
- SKU:
- PACO49357
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | TBX21 Antibody, Biotin conjugated (PACO49357) |
抗体コード: | PACO49357 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human T-box transcription factor TBX21 protein (82-395AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. |
シノニム: | T-box transcription factor TBX21 (T-box protein 21) (T-cell-specific T-box transcription factor T-bet) (Transcription factor TBLYM), TBX21, TBET TBLYM |
UniProt Protein Function: | TBX21: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. T-cell specific. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 17q21.32 Cellular Component: cell soma; nucleus Molecular Function:transcription factor activity Biological Process: positive regulation of isotype switching to IgG isotypes; transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to virus; positive regulation of transcription, DNA-dependent; multicellular organismal development; T cell differentiation Disease: Asthma, Nasal Polyps, And Aspirin Intolerance |
NCBI Summary: | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UL17 |
NCBI GenInfo Identifier: | 12230772 |
NCBI Gene ID: | 30009 |
NCBI Accession: | Q9UL17.1 |
UniProt Related Accession: | Q9UL17 |
Molecular Weight: | 58,328 Da |
NCBI Full Name: | T-box transcription factor TBX21 |
NCBI Synonym Full Names: | T-box 21 |
NCBI Official Symbol: | TBX21 |
NCBI Official Synonym Symbols: | TBET; T-PET; T-bet; TBLYM |
NCBI Protein Information: | T-box transcription factor TBX21; T-box protein 21; T-box expressed in T cells; transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet |
UniProt Protein Name: | T-box transcription factor TBX21 |
UniProt Synonym Protein Names: | T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM |
Protein Family: | T-box transcription factor |
UniProt Gene Name: | TBX21 |