TAX1BP1 Antibody (PACO15143)
- SKU:
- PACO15143
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | TAX1BP1 Antibody (PACO15143) |
抗体コード: | PACO15143 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human TAX1BP1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15143(TAX1BP1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15143(TAX1BP1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[ |
シノニム: | Tax1 (human T-cell leukemia virus type I) binding protein 1 |
UniProt Protein Function: | TAX1BP1: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1. Expressed in all tissues tested. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 7p15 Cellular Component: cytosol Molecular Function:kinase binding; protein binding Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of interferon type I production |
NCBI Summary: | This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011] |
UniProt Code: | Q86VP1 |
NCBI GenInfo Identifier: | 97202549 |
NCBI Gene ID: | 8887 |
NCBI Accession: | Q86VP1.2 |
UniProt Secondary Accession: | Q86VP1,O60398, O95770, Q13311, Q9BQG5, Q9UI88, A4D196 B4DKU7, E7ENV2, |
UniProt Related Accession: | Q86VP1 |
Molecular Weight: | 68,277 Da |
NCBI Full Name: | Tax1-binding protein 1 |
NCBI Synonym Full Names: | Tax1 binding protein 1 |
NCBI Official Symbol: | TAX1BP1 |
NCBI Official Synonym Symbols: | T6BP; TXBP151; CALCOCO3 |
NCBI Protein Information: | tax1-binding protein 1 |
UniProt Protein Name: | Tax1-binding protein 1 |
UniProt Synonym Protein Names: | TRAF6-binding protein |
Protein Family: | Tax1-binding protein |
UniProt Gene Name: | TAX1BP1 |
UniProt Entry Name: | TAXB1_HUMAN |