SYVN1 Antibody (PACO15072)
- SKU:
- PACO15072
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SYVN1 Antibody (PACO15072) |
抗体コード: | PACO15072 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human SYVN1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO15072(SYVN1 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Lovo cells, hela cells, 293T cells, Primary antibody: PACO15072(SYVN1 Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15072(SYVN1 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. |
シノニム: | Synovial apoptosis inhibitor 1, synoviolin |
UniProt Protein Function: | SYVN1: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Belongs to the HRD1 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; EC 6.3.2.-; Endoplasmic reticulum; Ligase; Ubiquitin ligase; Membrane protein, multi-pass; EC 6.3.2.19; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane Molecular Function:protein binding; acid-amino acid ligase activity; zinc ion binding Biological Process: ER-associated protein catabolic process; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; unfolded protein response; in utero embryonic development; protein ubiquitination; protein amino acid N-linked glycosylation via asparagine |
NCBI Summary: | This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011] |
UniProt Code: | Q86TM6 |
NCBI GenInfo Identifier: | 134035039 |
NCBI Gene ID: | 84447 |
NCBI Accession: | Q86TM6.2 |
UniProt Secondary Accession: | Q86TM6,Q8N3K3, Q8N6E8, Q96JL5, Q96PK3, |
UniProt Related Accession: | Q86TM6 |
Molecular Weight: | 617 |
NCBI Full Name: | E3 ubiquitin-protein ligase synoviolin |
NCBI Synonym Full Names: | synovial apoptosis inhibitor 1, synoviolin |
NCBI Official Symbol: | SYVN1 |
NCBI Official Synonym Symbols: | DER3; HRD1 |
NCBI Protein Information: | E3 ubiquitin-protein ligase synoviolin; HMG-coA reductase degradation 1 homolog |
UniProt Protein Name: | E3 ubiquitin-protein ligase synoviolin |
UniProt Synonym Protein Names: | Synovial apoptosis inhibitor 1 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | SYVN1 |
UniProt Entry Name: | SYVN1_HUMAN |