SUMO3 Antibody, HRP conjugated (PACO52071)
- SKU:
- PACO52071
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | SUMO3 Antibody, HRP conjugated (PACO52071) |
抗体コード: | PACO52071 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Small ubiquitin-related modifier 3 protein (1-92AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX. |
シノニム: | Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A), SUMO3, SMT3A SMT3H1 |
UniProt Protein Function: | SUMO3: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Covalently attached to a number of proteins. Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I. Expressed predominantly in liver. Belongs to the ubiquitin family. SUMO subfamily. |
UniProt Protein Details: | Protein type:Ubiquitin-like modifier Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: kinetochore; nucleoplasm; PML body; cytoplasm; nucleus Molecular Function:protein binding; SUMO ligase activity Biological Process: cellular protein metabolic process; protein sumoylation; post-translational protein modification |
NCBI Summary: | This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014] |
UniProt Code: | P55854 |
NCBI GenInfo Identifier: | 23503102 |
NCBI Gene ID: | 6612 |
NCBI Accession: | P55854.2 |
UniProt Related Accession: | P55854 |
Molecular Weight: | |
NCBI Full Name: | Small ubiquitin-related modifier 3 |
NCBI Synonym Full Names: | small ubiquitin like modifier 3 |
NCBI Official Symbol: | SUMO3 |
NCBI Official Synonym Symbols: | SMT3A; Smt3B; SMT3H1; SUMO-3 |
NCBI Protein Information: | small ubiquitin-related modifier 3 |
UniProt Protein Name: | Small ubiquitin-related modifier 3 |
UniProt Synonym Protein Names: | SMT3 homolog 1; SUMO-2; Ubiquitin-like protein SMT3A |
UniProt Gene Name: | SUMO3 |
UniProt Entry Name: | SUMO3_HUMAN |