SUCLG1 Antibody (PACO58933)
- SKU:
- PACO58933
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 抗体名: | SUCLG1 Antibody (PACO58933) |
| 抗体コード: | PACO58933 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial protein (210-316AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO58933 diluted at 1:600 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| バックグラウンド: | Succinyl-CoA synthetase functions in the citric acid, cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The α subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different β subunits. |
| シノニム: | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha), SUCLG1 |
| UniProt Protein Function: | SUCLG1: Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity. Heterodimer of an alpha and a beta subunit. Belongs to the succinate/malate CoA ligase alpha subunit family. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - propanoate; Mitochondrial; EC 6.2.1.4; Carbohydrate Metabolism - citrate (TCA) cycle; EC 6.2.1.5; Ligase Chromosomal Location of Human Ortholog: 2p11.2 Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane; cytoplasm; plasma membrane Molecular Function:succinate-CoA ligase (GDP-forming) activity; GDP binding; GTP binding; ATP citrate synthase activity; protein heterodimerization activity; cofactor binding; succinate-CoA ligase (ADP-forming) activity Biological Process: cellular metabolic process; succinate metabolic process; tricarboxylic acid cycle; succinyl-CoA metabolic process Disease: Mitochondrial Dna Depletion Syndrome 9 (encephalomyopathic Type With Methylmalonic Aciduria) |
| NCBI Summary: | This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010] |
| UniProt Code: | P53597 |
| NCBI GenInfo Identifier: | 1122286 |
| NCBI Gene ID: | 8802 |
| NCBI Accession: | CAA92426.1 |
| UniProt Secondary Accession: | P53597,Q9BWB0, Q9UNP6, |
| UniProt Related Accession: | P53597 |
| Molecular Weight: | 36,250 Da |
| NCBI Full Name: | succinyl coenzyme A synthetase |
| NCBI Synonym Full Names: | succinate-CoA ligase, alpha subunit |
| NCBI Official Symbol: | SUCLG1 |
| NCBI Official Synonym Symbols: | GALPHA; MTDPS9; SUCLA1 |
| NCBI Protein Information: | succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; SCS-alpha; succinyl-CoA synthetase subunit alpha; succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial |
| UniProt Protein Name: | Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial |
| UniProt Synonym Protein Names: | Succinyl-CoA synthetase subunit alpha |
| UniProt Gene Name: | SUCLG1 |
| UniProt Entry Name: | SUCA_HUMAN |