STXBP1 Antibody (PACO55022)
- SKU:
- PACO55022
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | STXBP1 Antibody (PACO55022) |
抗体コード: | PACO55022 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Rat, Mouse |
免疫原: | Recombinant Human Syntaxin-binding protein 1 protein (245-594AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Rat brain tissue, Mouse brain tissue. All lanes: STXBP1 antibody at 2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 68, 69 kDa. Observed band size: 68, 69 kDa. | |
Immunofluorescent analysis of Hela cells using PACO55022 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human melanoma using PACO55022 at dilution of 1:100. |
バックグラウンド: | May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. |
シノニム: | Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67), STXBP1, UNC18A |
UniProt Protein Function: | STXBP1: may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. Two splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 9q34.1 Cellular Component: cytoplasm; cytosol; mitochondrion; myelin sheath; nucleoplasm; plasma membrane; protein complex; terminal button Molecular Function:identical protein binding; protein binding; protein domain specific binding; protein kinase binding; protein N-terminus binding; SNARE binding; syntaxin binding; syntaxin-1 binding Biological Process: axon target recognition; energy reserve metabolic process; glutamate secretion; negative regulation of neuron apoptosis; negative regulation of synaptic transmission, GABAergic; neuromuscular synaptic transmission; neurotransmitter secretion; platelet degranulation; positive regulation of calcium ion-dependent exocytosis; protein stabilization; protein transport; regulation of insulin secretion; regulation of synaptic vesicle fusion to presynaptic membrane; synaptic transmission; synaptic vesicle maturation; vesicle docking during exocytosis Disease: Epileptic Encephalopathy, Early Infantile, 4 |
NCBI Summary: | This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010] |
UniProt Code: | P61764 |
NCBI GenInfo Identifier: | 50403646 |
NCBI Gene ID: | 6812 |
NCBI Accession: | P61764.1 |
UniProt Secondary Accession: | P61764,Q28208, Q62759, Q64320, Q96TG8, B1AM97, |
UniProt Related Accession: | P61764 |
Molecular Weight: | 68,736 Da |
NCBI Full Name: | Syntaxin-binding protein 1 |
NCBI Synonym Full Names: | syntaxin binding protein 1 |
NCBI Official Symbol: | STXBP1 |
NCBI Official Synonym Symbols: | P67; NSEC1; UNC18; RBSEC1; MUNC18-1 |
NCBI Protein Information: | syntaxin-binding protein 1 |
UniProt Protein Name: | Syntaxin-binding protein 1 |
UniProt Synonym Protein Names: | MUNC18-1; N-Sec1; Protein unc-18 homolog 1; Unc18-1; Protein unc-18 homolog A; Unc-18A; p67 |
Protein Family: | Syntaxin-binding protein |
UniProt Gene Name: | STXBP1 |
UniProt Entry Name: | STXB1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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