STX16 Antibody (PACO17192)
- SKU:
- PACO17192
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | STX16 Antibody (PACO17192) |
抗体コード: | PACO17192 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human STX16 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO17192(STX16 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: MCF7 cells, A172 cells, hepg2 cells, Primary antibody: PACO17192(STX16 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17192(STX16 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. |
シノニム: | syntaxin 16 |
UniProt Protein Function: | STX16: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. Genetic variations in STX16 may be a cause of pseudohypoparathyroidism type 1B (PHP1B). Pseudohypoparathyroidism refers to a heterogeneous group of disorders characterized by resistance to parathyroid hormone (PTH). PHP1B is characterized by PTH-resistant hypocalcemia and hyperphosphatemia. Patients affected with PHP1B lack developmental defects characteristic of Albright hereditary osteodystrophy, and typically show no other endocrine abnormalities besides resistance to PTH. In some cases microdeletions involving STX16 appear to cause loss of methylation at exon A/B of the GNAS gene, resulting in PHP1B. Belongs to the syntaxin family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Vesicle Chromosomal Location of Human Ortholog: 20q13.32 Cellular Component: cytoplasm; focal adhesion; Golgi apparatus; Golgi cisterna; Golgi membrane; integral to membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; SNARE complex; trans-Golgi network; trans-Golgi network membrane Molecular Function:protein binding; SNAP receptor activity; syntaxin binding Biological Process: intracellular protein transport; retrograde transport, endosome to Golgi; vesicle docking; vesicle fusion Disease: Pseudohypoparathyroidism, Type Ib |
NCBI Summary: | This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011] |
UniProt Code: | O14662 |
NCBI GenInfo Identifier: | 85700437 |
NCBI Gene ID: | 8675 |
NCBI Accession: | O14662.3 |
UniProt Secondary Accession: | O14662,O14661, O14663, O60517, A6NK32, A6NN69, A8MPP0 B7ZBN1, B7ZBN2, B7ZBN3, E1P5M0, E1P607, |
UniProt Related Accession: | O14662 |
Molecular Weight: | 31,074 Da |
NCBI Full Name: | Syntaxin-16 |
NCBI Synonym Full Names: | syntaxin 16 |
NCBI Official Symbol: | STX16 |
NCBI Official Synonym Symbols: | SYN16 |
NCBI Protein Information: | syntaxin-16 |
UniProt Protein Name: | Syntaxin-16 |
Protein Family: | Syntaxin |
UniProt Gene Name: | STX16 |
UniProt Entry Name: | STX16_HUMAN |