STK24 Antibody, FITC conjugated (PACO25194)
- SKU:
- PACO25194
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Description
抗体名: | STK24 Antibody, FITC conjugated (PACO25194) |
抗体コード: | PACO25194 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Serine/threonine-protein kinase 24 protein (1-431AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. |
シノニム: | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)], STK24, MST3 STK3 |
UniProt Protein Function: | MST3: a protein kinase of the STE20 family. Activated by caspase-mediated cleavage |
UniProt Protein Details: | Protein type:Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; STE group; STE20 family; YSK subfamily Chromosomal Location of Human Ortholog: 13q31.2-q32.3 Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nucleus; cytosol Molecular Function:protein serine/threonine kinase activity; protein binding; metal ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity Biological Process: regulation of axon regeneration; response to hydrogen peroxide; apoptosis; protein amino acid autophosphorylation; signal transduction; induction of apoptosis by oxidative stress; protein amino acid phosphorylation; negative regulation of cell migration; cell structure disassembly during apoptosis |
NCBI Summary: | This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] |
UniProt Code: | Q9Y6E0 |
NCBI GenInfo Identifier: | 13626607 |
NCBI Gene ID: | 8428 |
NCBI Accession: | Q9Y6E0.1 |
UniProt Secondary Accession: | Q9Y6E0,O14840, Q5JV92, |
UniProt Related Accession: | Q9Y6E0 |
Molecular Weight: | 47,913 Da |
NCBI Full Name: | Serine/threonine-protein kinase 24 |
NCBI Synonym Full Names: | serine/threonine kinase 24 |
NCBI Official Symbol: | STK24 |
NCBI Official Synonym Symbols: | MST3; STK3; MST3B; STE20; HEL-S-95 |
NCBI Protein Information: | serine/threonine-protein kinase 24; STE20-like kinase 3; STE20-like kinase MST3; sterile 20-like kinase 3; epididymis secretory protein Li 95; mammalian STE20-like protein kinase 3; serine/threonine kinase 24 (STE20 homolog, yeast) |
UniProt Protein Name: | Serine/threonine-protein kinase 24 |
UniProt Synonym Protein Names: | Mammalian STE20-like protein kinase 3; MST-3; STE20-like kinase MST3Cleaved into the following 2 chains:Serine/threonine-protein kinase 24 36 kDa subunitAlternative name(s):Mammalian STE20-like protein kinase 3 N-terminal; MST3/N |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | STK24 |
UniProt Entry Name: | STK24_HUMAN |