STK17B Antibody (PACO15775)
- SKU:
- PACO15775
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | STK17B Antibody (PACO15775) |
抗体コード: | PACO15775 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human STK17B |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15775(STK17B Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15775(STK17B Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | The full-length STK17B cDNA clone encodes a deduced 372-amino acid, protein with a molecular mass of 42.34 kD. The putative kinase domain is located at the N terminus and contains all 11 subdomains conserved among ser/thr kinases. STK17A and STK17B share 59.7% amino acid, identity. Northern blot analysis revealed that STK17B was expressed in various tissues, such as heart, placenta, liver, and pancreas, as different-sized transcripts, presumably due to differences in the 3-prime untranslated region. Transient transfection of COS-7 cells showed that STK17B localized in nuclei. Phosphorylates myosin light chains. Acts as a positive regulator of apoptosis. |
シノニム: | serine/threonine kinase 17b |
UniProt Protein Function: | DRAK2: a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.Protein type: EC 2.7.11.1; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; DAPK familyChromosomal Location of Human Ortholog: 2q32.3Cellular Component: nucleusMolecular Function: ATP binding; protein kinase activity; protein serine/threonine kinase activityBiological Process: protein amino acid autophosphorylation; protein amino acid phosphorylation |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | O94768 |
NCBI GenInfo Identifier: | 14423909 |
NCBI Gene ID: | 9262 |
NCBI Accession: | O94768.1 |
UniProt Secondary Accession: | O94768 |
UniProt Related Accession: | O94768 |
Molecular Weight: | 42,344 Da |
NCBI Full Name: | Serine/threonine-protein kinase 17B |
NCBI Synonym Full Names: | serine/threonine kinase 17b |
NCBI Official Symbol: | STK17B |
NCBI Official Synonym Symbols: | DRAK2 |
NCBI Protein Information: | serine/threonine-protein kinase 17B |
UniProt Protein Name: | Serine/threonine-protein kinase 17B |
UniProt Synonym Protein Names: | DAP kinase-related apoptosis-inducing protein kinase 2 |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | STK17B |
UniProt Entry Name: | ST17B_HUMAN |
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