STIM2 Antibody, Biotin conjugated (PACO48477)
- SKU:
- PACO48477
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | STIM2 Antibody, Biotin conjugated (PACO48477) |
抗体コード: | PACO48477 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Stromal interaction molecule 2 protein (471-656AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. |
シノニム: | Stromal interaction molecule 2, STIM2, KIAA1482 |
UniProt Protein Function: | Plays a role in mediating store-operated Ca2+ entry (SOCE), a Ca2+ influx following depletion of intracellular Ca2+ stores. Functions as a highly sensitive Ca2+ sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca2+-influx. Regulates basal cytosolic and endoplasmic reticulum Ca2+ concentrations. Upon mild variations of the endoplasmic reticulum Ca2+ concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca2+ release-activated Ca2+ (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca2+ influx. |
NCBI Summary: | This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009] |
UniProt Code: | Q9P246 |
NCBI GenInfo Identifier: | 17369338 |
NCBI Gene ID: | 57620 |
NCBI Accession: | Q9P246.2 |
UniProt Secondary Accession: | Q9P246,Q96BF1, Q9BQH2, Q9H8R1, A6H8L7, B7ZVY0, |
UniProt Related Accession: | Q9P246 |
Molecular Weight: | 68,026 Da |
NCBI Full Name: | Stromal interaction molecule 2 |
NCBI Synonym Full Names: | stromal interaction molecule 2 |
NCBI Official Symbol: | STIM2 |
NCBI Protein Information: | stromal interaction molecule 2 |
UniProt Protein Name: | Stromal interaction molecule 2 |
Protein Family: | Stromal interaction molecule |
UniProt Gene Name: | STIM2 |
UniProt Entry Name: | STIM2_HUMAN |