STAMBP Antibody, HRP conjugated (PACO30163)
- SKU:
- PACO30163
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | STAMBP Antibody, HRP conjugated (PACO30163) |
抗体コード: | PACO30163 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human STAM-binding protein (1-424AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization.Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. |
シノニム: | STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase), STAMBP, AMSH |
UniProt Protein Function: | AMSH: an adaptor protein involved in cytokine signal transduction the JAK-STAT cascade. Binds to the SH3 domain of the signal-transducing adaptor molecule STAM (signal transducing adaptor molecule). May play a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. |
UniProt Protein Details: | Protein type:EC 3.1.2.15; Protease; Ubiquitin-specific protease; EC 3.4.19.- Chromosomal Location of Human Ortholog: 2p13.1 Cellular Component: cleavage furrow; cytoplasm; nucleoplasm; nucleus; plasma membrane Molecular Function:protein binding; protein domain specific binding; ubiquitin-specific protease activity Biological Process: cytokinesis after mitosis; JAK-STAT cascade; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of Ras protein signal transduction; positive regulation of cell proliferation; protein deubiquitination Disease: Microcephaly-capillary Malformation Syndrome |
NCBI Summary: | Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O95630 |
NCBI GenInfo Identifier: | 71153538 |
NCBI Gene ID: | 10617 |
NCBI Accession: | O95630.1 |
UniProt Secondary Accession: | O95630,Q3MJE7, B5M0B6, D6W5H7, |
UniProt Related Accession: | O95630 |
Molecular Weight: | 39,596 Da |
NCBI Full Name: | STAM-binding protein |
NCBI Synonym Full Names: | STAM binding protein |
NCBI Official Symbol: | STAMBP |
NCBI Official Synonym Symbols: | AMSH; MICCAP |
NCBI Protein Information: | STAM-binding protein |
UniProt Protein Name: | STAM-binding protein |
UniProt Synonym Protein Names: | Associated molecule with the SH3 domain of STAM; Endosome-associated ubiquitin isopeptidase |
Protein Family: | STAM-binding protein |
UniProt Gene Name: | STAMBP |
UniProt Entry Name: | STABP_HUMAN |