ST3GAL5 Antibody (PACO44979)
- SKU:
- PACO44979
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | ST3GAL5 Antibody (PACO44979) |
抗体コード: | PACO44979 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
反応性: | Human |
免疫原: | Recombinant Human Lactosylceramide alpha-2,3-sialyltransferase protein (80-200AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: ST3GAL5 antibody at 6.2 µg/ml. Lane 1: K562 whole cell lysate. Lane 2: U251 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 48, 46 kDa. Observed band size: 48, 60 kDa.. |
バックグラウンド: | Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide). |
シノニム: | Lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.99.9) (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase) (Ganglioside GM3 synthase) (ST3Gal V) (ST3GalV) (Sialyltransferase 9), ST3GAL5, SIAT9 |
UniProt Protein Function: | ST3GAL5: Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide). Defects in ST3GAL5 are the cause of Amish infantile epilepsy syndrome (AIES). AIES is an autosomal recessive, infantile-onset symptomatic epilepsy associated with developmental stagnation and blindness. Belongs to the glycosyltransferase 29 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; EC 2.4.99.9; Transferase Chromosomal Location of Human Ortholog: 2p11.2 Cellular Component: Golgi membrane; integral to plasma membrane; integral to membrane; integral to Golgi membrane Molecular Function:lactosylceramide alpha-2,3-sialyltransferase activity; neolactotetraosylceramide alpha-2,3-sialyltransferase activity; sialyltransferase activity Biological Process: cellular protein metabolic process; glycosphingolipid biosynthetic process; dolichol-linked oligosaccharide biosynthetic process; carbohydrate metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; ganglioside biosynthetic process Disease: Amish Infantile Epilepsy Syndrome |
NCBI Summary: | Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UNP4 |
NCBI GenInfo Identifier: | 109633044 |
NCBI Gene ID: | 8869 |
NCBI Accession: | NP_003887.3 |
UniProt Secondary Accession: | Q9UNP4,O94902, Q53QU1, Q6NZX4, Q6YFL1, B3KM82, D6W5L9 |
UniProt Related Accession: | Q9UNP4 |
Molecular Weight: | 45,585 Da |
NCBI Full Name: | lactosylceramide alpha-2,3-sialyltransferase isoform 1 |
NCBI Synonym Full Names: | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 |
NCBI Official Symbol: | ST3GAL5 |
NCBI Official Synonym Symbols: | SATI; SIAT9; ST3GalV; SIATGM3S |
NCBI Protein Information: | lactosylceramide alpha-2,3-sialyltransferase |
UniProt Protein Name: | Lactosylceramide alpha-2,3-sialyltransferase |
UniProt Synonym Protein Names: | CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; Ganglioside GM3 synthase; ST3Gal V; ST3GalV; Sialyltransferase 9 |
Protein Family: | Lactosylceramide alpha-2,3-sialyltransferase |
UniProt Gene Name: | ST3GAL5 |
UniProt Entry Name: | SIAT9_HUMAN |