SRRT Antibody (PACO43942)
- SKU:
- PACO43942
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SRRT Antibody (PACO43942) |
抗体コード: | PACO43942 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Serrate RNA effector molecule homolog protein (627-876AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43942 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO43942 at dilution of 1:100. |
バックグラウンド: | Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity). |
シノニム: | Serrate RNA effector molecule homolog (Arsenite-resistance protein 2), SRRT, ARS2 ASR2 |
UniProt Protein Function: | SRRT: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. Belongs to the ARS2 family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA-binding; RNA processing; Spliceosome Chromosomal Location of Human Ortholog: 7q21 Cellular Component: cytoplasm; nucleoplasm Molecular Function:DNA binding; protein binding Biological Process: cell proliferation; nuclear mRNA splicing, via spliceosome; primary microRNA processing; regulation of transcription, DNA-dependent; snRNA transcription from RNA polymerase II promoter |
UniProt Code: | Q9BXP5 |
NCBI GenInfo Identifier: | 20137457 |
NCBI Gene ID: | 51593 |
NCBI Accession: | Q9BXP5.1 |
UniProt Secondary Accession: | Q9BXP5,O95808, Q32MI4, Q6NT74, Q8TDQ5, Q9BWP6, Q9BXP4 A4D2E5, A4D2E6, A6NK22, B4DJL4, B4DZA6, |
UniProt Related Accession: | Q9BXP5 |
Molecular Weight: | 96,222 Da |
NCBI Full Name: | Serrate RNA effector molecule homolog |
NCBI Synonym Full Names: | serrate, RNA effector molecule |
NCBI Official Symbol: | SRRT |
NCBI Official Synonym Symbols: | ARS2; ASR2; serrate |
NCBI Protein Information: | serrate RNA effector molecule homolog |
UniProt Protein Name: | Serrate RNA effector molecule homolog |
UniProt Synonym Protein Names: | Arsenite-resistance protein 2 |
UniProt Gene Name: | SRRT |
UniProt Entry Name: | SRRT_HUMAN |
Antibodies |
Anti-SRRT Antibody (CAB8219) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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