SRA1 Antibody (PACO12452)
- SKU:
- PACO12452
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SRA1 Antibody (PACO12452) |
抗体コード: | PACO12452 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human |
免疫原: | Human SRA1 |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | steroid receptor RNA activator 1;SRA1;MGC87674;SRA;SRAP;STRAA1;pp7684 ; |
UniProt Protein Function: | SRA1: Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. Belongs to the SRA1 family. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 5q31.3 Cellular Component: nucleoplasm; microtubule cytoskeleton; intercellular bridge; cytoplasm; plasma membrane; nucleus; ribonucleoprotein complex Molecular Function:protein binding; ligand-dependent nuclear receptor transcription coactivator activity; transcription coactivator activity Biological Process: regulation of apoptosis; cell proliferation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; apoptosis; cell differentiation |
NCBI Summary: | Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012] |
UniProt Code: | Q9HD15 |
NCBI GenInfo Identifier: | 74718904 |
NCBI Gene ID: | 10011 |
NCBI Accession: | Q9HD15.1 |
UniProt Secondary Accession: | Q9HD15,Q6NVU9, Q8IXM1, Q9HD13, Q9HD14, |
UniProt Related Accession: | Q9HD15 |
Molecular Weight: | 25,673 Da |
NCBI Full Name: | Steroid receptor RNA activator 1 |
NCBI Synonym Full Names: | steroid receptor RNA activator 1 |
NCBI Official Symbol: | SRA1 |
NCBI Official Synonym Symbols: | SRA; SRAP; STRAA1; pp7684 |
NCBI Protein Information: | steroid receptor RNA activator 1; SRA1; steroid receptor coactivator; steroid receptor RNA activator protein; steroid receptor RNA activator 1 (complexes with NCOA1) |
UniProt Protein Name: | Steroid receptor RNA activator 1 |
UniProt Synonym Protein Names: | Steroid receptor RNA activator protein; SRAP |
Protein Family: | Steroid receptor RNA activator |
UniProt Gene Name: | SRA1 |
UniProt Entry Name: | SRA1_HUMAN |