SPRTN Antibody, HRP conjugated (PACO40535)
- SKU:
- PACO40535
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | SPRTN Antibody, HRP conjugated (PACO40535) |
抗体コード: | PACO40535 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human SprT-like domain-containing protein Spartan protein (1-239AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. |
シノニム: | SprT-like domain-containing protein Spartan (DNA damage protein targeting VCP) (DVC1) (Protein with SprT-like domain at the N terminus) (Spartan), SPRTN, C1orf124 DVC1 |
UniProt Protein Function: | SPRTN: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Also required for localization of DNA polymerase eta (POLH) to sites of UV damage. Belongs to the Spartan family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 1q42.2 Cellular Component: nuclear speck; nucleoplasm; nucleus Molecular Function:protein binding; ubiquitin binding Biological Process: bypass DNA synthesis; positive regulation of protein ubiquitination; response to DNA damage stimulus; response to UV Disease: Ruijs-aalfs Syndrome |
NCBI Summary: | The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015] |
UniProt Code: | Q9H040 |
NCBI GenInfo Identifier: | 162416221 |
NCBI Gene ID: | 83932 |
NCBI Accession: | Q9H040.2 |
UniProt Secondary Accession: | Q9H040,Q5TE78, Q6UWW6, Q96BC5, Q96KA0, B1AKT0, B5MEF7 |
UniProt Related Accession: | Q9H040 |
Molecular Weight: | 55kDa |
NCBI Full Name: | SprT-like domain-containing protein Spartan |
NCBI Synonym Full Names: | SprT-like N-terminal domain |
NCBI Official Symbol: | SPRTN |
NCBI Official Synonym Symbols: | DVC1; PRO4323; spartan; C1orf124 |
NCBI Protein Information: | sprT-like domain-containing protein Spartan |
UniProt Protein Name: | SprT-like domain-containing protein Spartan |
UniProt Synonym Protein Names: | DNA damage protein targeting VCP; DVC1; Protein with SprT-like domain at the N terminus; Spartan |
UniProt Gene Name: | SPRTN |