SPRED1 Antibody, Biotin conjugated (PACO52505)
- SKU:
- PACO52505
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | SPRED1 Antibody, Biotin conjugated (PACO52505) |
抗体コード: | PACO52505 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Sprouty-related, EVH1 domain-containing protein 1 protein (123-311AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity). |
シノニム: | Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1), SPRED1 |
UniProt Protein Function: | SPRED1: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Defects in SPRED1 are the cause of neurofibromatosis type 1-like syndrome (NFLS). It is a disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity. |
UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 15q14 Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane Molecular Function:phosphatase binding; protein binding; protein kinase binding; protein serine/threonine kinase inhibitor activity; stem cell factor receptor binding Biological Process: fibroblast growth factor receptor signaling pathway; inactivation of MAPK activity; MAPKKK cascade; positive regulation of DNA damage response, signal transduction by p53 class mediator Disease: Legius Syndrome |
NCBI Summary: | The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008] |
UniProt Code: | Q7Z699 |
NCBI GenInfo Identifier: | 57013078 |
NCBI Gene ID: | 161742 |
NCBI Accession: | Q7Z699.2 |
UniProt Secondary Accession: | Q7Z699,Q05D53, Q8N256, B2RPJ8, |
UniProt Related Accession: | Q7Z699 |
Molecular Weight: | 50,477 Da |
NCBI Full Name: | Sprouty-related, EVH1 domain-containing protein 1 |
NCBI Synonym Full Names: | sprouty related EVH1 domain containing 1 |
NCBI Official Symbol: | SPRED1 |
NCBI Official Synonym Symbols: | NFLS; hSpred1; spred-1; PPP1R147 |
NCBI Protein Information: | sprouty-related, EVH1 domain-containing protein 1 |
UniProt Protein Name: | Sprouty-related, EVH1 domain-containing protein 1 |
Protein Family: | Sprouty-related, EVH1 domain-containing protein |
UniProt Gene Name: | SPRED1 |
UniProt Entry Name: | SPRE1_HUMAN |