SPINT2 Antibody, HRP conjugated (PACO53363)
- SKU:
- PACO53363
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | SPINT2 Antibody, HRP conjugated (PACO53363) |
抗体コード: | PACO53363 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Kunitz-type protease inhibitor 2 protein (71-194AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. |
シノニム: | Kunitz-type protease inhibitor 2 (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin), SPINT2, HAI2 KOP |
UniProt Protein Function: | SPINT2: Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. Defects in SPINT2 are the cause of diarrhea type 3 (DIAR3); also known as congenital sodium diarrhea (CSD). DIAR3 is a rare, inherited diarrhea of infancy. A diagnosis of DIAR3 is made on the findings of a life-threatening secretory diarrhea, severe metabolic acidosis, and hyponatremia secondary to extraordinarily high fecal losses of sodium, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune, and endocrine causes. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Inhibitor; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: cytoplasm; extracellular region; integral to membrane Molecular Function:serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity Biological Process: cell motility Disease: Diarrhea 3, Secretory Sodium, Congenital, With Or Without Other Congenital Anomalies |
NCBI Summary: | This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
UniProt Code: | O43291 |
NCBI GenInfo Identifier: | 13124550 |
NCBI Gene ID: | 10653 |
NCBI Accession: | O43291.2 |
UniProt Secondary Accession: | O43291,O00271, O14895, Q5TZQ3, Q969E0, A8K667, B4DLU1 |
UniProt Related Accession: | O43291 |
Molecular Weight: | 252 |
NCBI Full Name: | Kunitz-type protease inhibitor 2 |
NCBI Synonym Full Names: | serine peptidase inhibitor, Kunitz type, 2 |
NCBI Official Symbol: | SPINT2 |
NCBI Official Synonym Symbols: | PB; Kop; HAI2; DIAR3; HAI-2 |
NCBI Protein Information: | kunitz-type protease inhibitor 2; placental bikunin; serine protease inhibitor, Kunitz type, 2; hepatocyte growth factor activator inhibitor type 2 |
UniProt Protein Name: | Kunitz-type protease inhibitor 2 |
UniProt Synonym Protein Names: | Hepatocyte growth factor activator inhibitor type 2; HAI-2; Placental bikunin |
Protein Family: | Kunitz-type protease inhibitor |
UniProt Gene Name: | SPINT2 |
UniProt Entry Name: | SPIT2_HUMAN |