SPG11 Antibody, FITC conjugated (PACO38992)
- SKU:
- PACO38992
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | SPG11 Antibody, FITC conjugated (PACO38992) |
抗体コード: | PACO38992 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Spatacsin protein (2019-2318AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | cytoplasm, cytoplasmic vesicle, extracellular exosome, lysosomal membrane, nucleolus, plasma membrane |
シノニム: | Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein), SPG11, KIAA1840 |
UniProt Protein Function: | SPG11: Defects in SPG11 are the cause of spastic paraplegia autosomal recessive type 11 (SPG11). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 15q21.1 Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; lysosomal membrane; nucleolus; plasma membrane; synapse Molecular Function:protein binding Biological Process: axon cargo transport; synaptic transmission; synaptic vesicle transport Disease: Amyotrophic Lateral Sclerosis 5, Juvenile; Charcot-marie-tooth Disease, Axonal, Type 2x; Spastic Paraplegia 11, Autosomal Recessive |
NCBI Summary: | The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
UniProt Code: | Q96JI7 |
NCBI GenInfo Identifier: | 296452946 |
NCBI Gene ID: | 80208 |
NCBI Accession: | Q96JI7.3 |
UniProt Secondary Accession: | Q96JI7,Q4VC11, Q58G86, Q69YG6, Q6NW01, Q8N270, Q8TBU9 Q9H734, A8KAX9, B9EK60, F5H3N6, |
UniProt Related Accession: | Q96JI7 |
Molecular Weight: | 279kDa |
NCBI Full Name: | Spatacsin |
NCBI Synonym Full Names: | SPG11, spatacsin vesicle trafficking associated |
NCBI Official Symbol: | SPG11 |
NCBI Official Synonym Symbols: | ALS5; CMT2X; KIAA1840 |
NCBI Protein Information: | spatacsin |
UniProt Protein Name: | Spatacsin |
UniProt Synonym Protein Names: | Colorectal carcinoma-associated protein; Spastic paraplegia 11 protein |
Protein Family: | Spatacsin |
UniProt Gene Name: | SPG11 |