SPDEF Antibody, HRP conjugated (PACO47691)
- SKU:
- PACO47691
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | SPDEF Antibody, HRP conjugated (PACO47691) |
抗体コード: | PACO47691 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human SAM pointed domain-containing Ets transcription factor protein (145-247AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. |
シノニム: | SAM pointed domain-containing Ets transcription factor (Prostate epithelium-specific Ets transcription factor) (Prostate-specific Ets) (Prostate-derived Ets factor), SPDEF, PDEF PSE |
UniProt Protein Function: | SPDEF: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. Belongs to the ETS family. |
UniProt Protein Details: | Protein type:Transcription factor; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; DNA-binding Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: nucleus Molecular Function:sequence-specific DNA binding Biological Process: transcription from RNA polymerase II promoter; positive regulation of cell fate commitment; positive regulation of apoptosis; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of cell fate commitment |
NCBI Summary: | The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
UniProt Code: | O95238 |
NCBI GenInfo Identifier: | 74762123 |
NCBI Gene ID: | 25803 |
NCBI Accession: | O95238.1 |
UniProt Secondary Accession: | O95238,B4DWH8, F5H778, |
UniProt Related Accession: | O95238 |
Molecular Weight: | 335 |
NCBI Full Name: | SAM pointed domain-containing Ets transcription factor |
NCBI Synonym Full Names: | SAM pointed domain containing ETS transcription factor |
NCBI Official Symbol: | SPDEF |
NCBI Official Synonym Symbols: | PDEF; bA375E1.3 |
NCBI Protein Information: | SAM pointed domain-containing Ets transcription factor; prostate-specific Ets; prostate-derived Ets factor; prostate epithelium-specific Ets transcription factor |
UniProt Protein Name: | SAM pointed domain-containing Ets transcription factor |
UniProt Synonym Protein Names: | Prostate epithelium-specific Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor |
Protein Family: | SAM pointed domain-containing Ets transcription factor |
UniProt Gene Name: | SPDEF |
UniProt Entry Name: | SPDEF_HUMAN |