SOS1 Antibody (PACO59125)
- SKU:
- PACO59125
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SOS1 Antibody (PACO59125) |
抗体コード: | PACO59125 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200 |
反応性: | Human, Rat |
免疫原: | Recombinant Human Son of sevenless homolog 1 protein (1140-1281AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Rat brain tissue. All lanes: SOS1 antibody at 4.6µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 153, 37 kDa. Observed band size: 153 kDa. | |
IHC image of PACO59125 diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. | |
IHC image of PACO59125 diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity). |
シノニム: | Son of sevenless homolog 1 (SOS-1), SOS1 |
UniProt Protein Function: | Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (PubMed:17339331). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity. |
NCBI Summary: | This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q07889 |
NCBI GenInfo Identifier: | 6094322 |
NCBI Gene ID: | 6654 |
NCBI Accession: | Q07889.1 |
UniProt Secondary Accession: | Q07889,A8K2G3, B4DXG2, |
UniProt Related Accession: | Q07889 |
Molecular Weight: | |
NCBI Full Name: | Son of sevenless homolog 1 |
NCBI Synonym Full Names: | SOS Ras/Rac guanine nucleotide exchange factor 1 |
NCBI Official Symbol: | SOS1 |
NCBI Official Synonym Symbols: | GF1; HGF; NS4; GGF1; GINGF; SOS-1 |
NCBI Protein Information: | son of sevenless homolog 1 |
UniProt Protein Name: | Son of sevenless homolog 1 |
Protein Family: | Son of sevenless |
UniProt Gene Name: | SOS1 |
Antibodies | ELISA Kits |
Anti-SOS1 Antibody (CAB3272) | Human SOS1 (Son of sevenless homolog 1) ELISA Kit (HUFI06402) |
SOS1 Antibody (PACO12397) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |