SOCS5 Antibody (PACO15013)
- SKU:
- PACO15013
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | SOCS5 Antibody (PACO15013) |
抗体コード: | PACO15013 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human SOCS5 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15013(SOCS5 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15013(SOCS5 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. |
シノニム: | suppressor of cytokine signaling 5 |
UniProt Protein Function: | SOCS5: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. |
UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 2p21 Cellular Component: cytoplasm Molecular Function:protein binding; protein kinase inhibitor activity; receptor tyrosine kinase binding; epidermal growth factor receptor binding Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor activity; negative regulation of T-helper 2 cell differentiation; regulation of growth; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; cytokine and chemokine mediated signaling pathway; protein ubiquitination; cell growth; positive regulation of T-helper 1 cell differentiation; JAK-STAT cascade; negative regulation of JAK-STAT cascade; negative regulation of signal transduction |
NCBI Summary: | The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008] |
UniProt Code: | O75159 |
NCBI GenInfo Identifier: | 7662240 |
NCBI Gene ID: | 9655 |
NCBI Accession: | NP_054730 |
UniProt Secondary Accession: | O75159,Q53SD4, Q8IYZ4, |
UniProt Related Accession: | O75159 |
Molecular Weight: | 61,246 Da |
NCBI Full Name: | suppressor of cytokine signaling 5 |
NCBI Synonym Full Names: | suppressor of cytokine signaling 5 |
NCBI Official Symbol: | SOCS5 |
NCBI Official Synonym Symbols: | CIS6; CISH6; Cish5; SOCS-5 |
NCBI Protein Information: | suppressor of cytokine signaling 5 |
UniProt Protein Name: | Suppressor of cytokine signaling 5 |
UniProt Synonym Protein Names: | Cytokine-inducible SH2 protein 6; CIS-6; Cytokine-inducible SH2-containing protein 5 |
Protein Family: | Suppressor of cytokine signaling |
UniProt Gene Name: | SOCS5 |
UniProt Entry Name: | SOCS5_HUMAN |