SNX6 Antibody, FITC conjugated (PACO42348)
- SKU:
- PACO42348
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | SNX6 Antibody, FITC conjugated (PACO42348) |
抗体コード: | PACO42348 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Sorting nexin-6 protein (1-290AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation. In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). |
シノニム: | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed], SNX6 |
UniProt Protein Function: | SNX6: May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B. Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation. Belongs to the sorting nexin family. |
UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 14q13.1 Cellular Component: cytoplasm; early endosome membrane; extrinsic to membrane; retromer complex Molecular Function:phosphoinositide binding; protein binding; protein homodimerization activity Biological Process: endocytosis; intracellular protein transport; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; retrograde transport, endosome to Golgi; vesicle organization and biogenesis |
NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UNH7 |
NCBI GenInfo Identifier: | 10720285 |
NCBI Gene ID: | 58533 |
NCBI Accession: | Q9UNH7.1 |
UniProt Secondary Accession: | Q9UNH7,Q9Y449, C0H5W9, |
UniProt Related Accession: | Q9UNH7 |
Molecular Weight: | 33,570 Da |
NCBI Full Name: | Sorting nexin-6 |
NCBI Synonym Full Names: | sorting nexin 6 |
NCBI Official Symbol: | SNX6 |
NCBI Official Synonym Symbols: | TFAF2; MSTP010 |
NCBI Protein Information: | sorting nexin-6 |
UniProt Protein Name: | Sorting nexin-6 |
UniProt Synonym Protein Names: | TRAF4-associated factor 2 |
Protein Family: | Sorting nexin |
UniProt Gene Name: | SNX6 |
UniProt Entry Name: | SNX6_HUMAN |