SNX17 Antibody (PACO48582)
- SKU:
- PACO48582
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | SNX17 Antibody (PACO48582) |
抗体コード: | PACO48582 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Sorting nexin-17 protein (280-457AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Mouse liver tissue, Mouse kidney tissue. All lanes: SNX17 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 53, 50 kDa. Observed band size: 53 kDa.. |
![]() | Immunofluorescent analysis of HepG2 cells using PACO48582 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO48582 at dilution of 1:100. |
バックグラウンド: | Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated α subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). |
シノニム: | Sorting nexin-17, SNX17, KIAA0064 |
UniProt Protein Function: | SNX17: May be involved in several stages of intracellular protein trafficking. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)). Belongs to the sorting nexin family. |
UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: cytoplasm; cytoplasmic membrane-bound vesicle; cytosol; early endosome; endosome; endosome membrane; Golgi apparatus; intracellular membrane-bound organelle; protein complex Molecular Function:low-density lipoprotein receptor binding; phosphoinositide binding; protein binding; protein C-terminus binding Biological Process: cholesterol catabolic process; intracellular protein transport |
NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012] |
UniProt Code: | Q15036 |
NCBI GenInfo Identifier: | 3123050 |
NCBI Gene ID: | 9784 |
NCBI Accession: | Q15036.1 |
UniProt Secondary Accession: | Q15036,Q53HN7, Q6IAS3, B4DQM7, |
UniProt Related Accession: | Q15036 |
Molecular Weight: | 49,999 Da |
NCBI Full Name: | Sorting nexin-17 |
NCBI Synonym Full Names: | sorting nexin 17 |
NCBI Official Symbol: | SNX17 |
NCBI Protein Information: | sorting nexin-17 |
UniProt Protein Name: | Sorting nexin-17 |
Protein Family: | Sorting nexin |
UniProt Gene Name: | SNX17 |
UniProt Entry Name: | SNX17_HUMAN |