SMYD2 Antibody, Biotin conjugated (PACO47201)
- SKU:
- PACO47201
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Description
抗体名: | SMYD2 Antibody, Biotin conjugated (PACO47201) |
抗体コード: | PACO47201 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human N-lysine methyltransferase SMYD2 protein (115-272AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. |
シノニム: | N-lysine methyltransferase SMYD2 (EC 2.1.1) (HSKM-B) (Histone methyltransferase SMYD2) (EC 2.1.1.43) (Lysine N-methyltransferase 3C) (SET and MYND domain-containing protein 2), SMYD2, KMT3C |
UniProt Protein Function: | SMYD2: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB. Interacts with RNA polymerase II and HELZ. Interacts with SIN3A and HDAC1. Interacts (via MYND-type zinc finger) with EPB41L3. Interacts (via SET domain) with p53/TP53. Interacts with RB1 and HSP90AA1. Expression is repressed by CEBPA. |
UniProt Protein Details: | Protein type:Methyltransferase, protein lysine; EC 2.1.1.43; Methyltransferase Chromosomal Location of Human Ortholog: 1q32.3 Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol Molecular Function:protein binding; p53 binding; metal ion binding; protein-lysine N-methyltransferase activity; histone lysine N-methyltransferase activity (H3-K36 specific) Biological Process: negative regulation of cell proliferation; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; peptidyl-lysine di-methylation; peptidyl-lysine mono-methylation; histone H3-K36 methylation; negative regulation of transcription from RNA polymerase II promoter; regulation of DNA damage response, signal transduction by p53 class mediator |
NCBI Summary: | SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008] |
UniProt Code: | Q9NRG4 |
NCBI GenInfo Identifier: | 90185234 |
NCBI Gene ID: | 56950 |
NCBI Accession: | Q9NRG4.2 |
UniProt Related Accession: | Q9NRG4 |
Molecular Weight: | 30kDa; 49kDa |
NCBI Full Name: | N-lysine methyltransferase SMYD2 |
NCBI Synonym Full Names: | SET and MYND domain containing 2 |
NCBI Official Symbol: | SMYD2 |
NCBI Official Synonym Symbols: | KMT3C; HSKM-B; ZMYND14 |
NCBI Protein Information: | N-lysine methyltransferase SMYD2 |
UniProt Protein Name: | N-lysine methyltransferase SMYD2 |
UniProt Synonym Protein Names: | HSKM-B; Histone methyltransferase SMYD2 (EC:2.1.1.43); Lysine N-methyltransferase 3C; SET and MYND domain-containing protein 2 |
Protein Family: | N-lysine methyltransferase |
UniProt Gene Name: | SMYD2 |
UniProt Entry Name: | SMYD2_HUMAN |