SMOX Antibody, Biotin conjugated (PACO55017)
- SKU:
- PACO55017
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | SMOX Antibody, Biotin conjugated (PACO55017) |
抗体コード: | PACO55017 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Spermine oxidase protein (268-353AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. |
シノニム: | Spermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1), SMOX, C20orf16 SMO |
UniProt Protein Function: | SMOX: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. Belongs to the flavin monoamine oxidase family. 6 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 1.5.3.16; Oxidoreductase Chromosomal Location of Human Ortholog: 20p13 Cellular Component: cytosol; intracellular membrane-bound organelle; nuclear membrane; nucleoplasm Molecular Function:polyamine oxidase activity Biological Process: polyamine biosynthetic process; polyamine catabolic process |
NCBI Summary: | Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012] |
UniProt Code: | Q9NWM0 |
NCBI GenInfo Identifier: | 50401688 |
NCBI Gene ID: | 54498 |
NCBI Accession: | Q9NWM0.1 |
UniProt Secondary Accession: | Q9NWM0,Q5TE26, Q5TE27, Q6UY28, Q8IX00, Q96LC3, Q96LC4 Q96QT3, A2A2P5, A2A2P6, A8BE87, D3DVZ4, |
UniProt Related Accession: | Q9NWM0 |
Molecular Weight: | 62kDa |
NCBI Full Name: | Spermine oxidase |
NCBI Synonym Full Names: | spermine oxidase |
NCBI Official Symbol: | SMOX |
NCBI Official Synonym Symbols: | PAO; SMO; PAO1; PAOH; PAO-1; PAOH1; C20orf16 |
NCBI Protein Information: | spermine oxidase |
UniProt Protein Name: | Spermine oxidase |
UniProt Synonym Protein Names: | Polyamine oxidase 1; PAO-1; PAOh1 |
Protein Family: | Spermine oxidase |
UniProt Gene Name: | SMOX |