SMG7 Antibody, HRP conjugated (PACO59294)
- SKU:
- PACO59294
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | SMG7 Antibody, HRP conjugated (PACO59294) |
抗体コード: | PACO59294 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Protein SMG7 protein (694-809AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. |
シノニム: | Protein SMG7 (EST1-like protein C) (SMG-7 homolog) (hSMG-7), SMG7, C1orf16 EST1C KIAA0250 |
UniProt Protein Function: | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. |
NCBI Summary: | This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q92540 |
NCBI GenInfo Identifier: | 84028262 |
NCBI Gene ID: | 9887 |
NCBI Accession: | Q92540.2 |
UniProt Secondary Accession: | Q92540,Q5T1Q0, Q6PIE0, Q7Z7H9, Q8IXC1, Q8IXC2, B4DRB2 E9PCI0, E9PEH2, |
UniProt Related Accession: | Q92540 |
Molecular Weight: | 127,854 Da |
NCBI Full Name: | Protein SMG7 |
NCBI Synonym Full Names: | SMG7, nonsense mediated mRNA decay factor |
NCBI Official Symbol: | SMG7 |
NCBI Official Synonym Symbols: | EST1C; SGA56M; C1orf16 |
NCBI Protein Information: | protein SMG7 |
UniProt Protein Name: | Protein SMG7 |
UniProt Synonym Protein Names: | EST1-like protein C; SMG-7 homolog; hSMG-7 |
Protein Family: | Protein |
UniProt Gene Name: | SMG7 |
UniProt Entry Name: | SMG7_HUMAN |